ABSTRACT
The Cardiac Troponin T and I are highly cardiac specific biochemical markers of myocardial injury. They are very sensitive markers to detect all kinds of myocardial injury, and are able to distinguish myocardial injury and skeletal injury. Furthermore, They are independent predictor of future cardiac events. Such markers are now widely used in the clinic practice. It is prospective to use them in Forensic Medical Science.
Subject(s)
Humans , Biomarkers , Forensic Medicine , Myocardial Infarction/blood , Myocardium/metabolism , Troponin I/blood , Troponin T/bloodABSTRACT
Calcitonin gene-related peptide (CGRP) play a key role in some physiological and pathological progresses. The latest studies indicate that CGRP might involve in some disease progress and has a close relation with wound healing. It is significant to further investigate and then apply it to clinical diagnosis and therapy as well as forensic pathology.
Subject(s)
Animals , Humans , Calcitonin Gene-Related Peptide/physiology , Forensic Medicine , Receptors, Calcitonin Gene-Related Peptide/physiology , Wound HealingABSTRACT
OBJECTIVE@#To evaluate changes of VEGF in skin after blunt injury.@*METHODS@#The rats of injury groups were subjected to skin blunt injury by free-falling iron hammer. The samples taken at 1 h, 3 h, 6 h, 12 h, 1 d, 3 d, 5 d, 7 d, 9 d after injury were studied by immunohistochemistry and MIAS image analysis system.@*RESULTS@#In the skin of normal control group the expression level of VEGF was low. The increase of VEGF could be observed at 1 day after injury, reached peak at 7 days and declined at 9 days.@*CONCLUSION@#Blunt injury in the skin could induce the expression of the VEGF. Moreover, the change pattern of VEGF level was quite regular with time and could be used to estimate the time after skin injury.